Furthermore, in multivariate Cox regression, downregulation of NLRP6 and IL-18 in the epithelium was associated with a worse outcome, after adjustment on TNM tumor stage (NLRP6: OR 3.25 [95CI: 1.27–8.28], p = 0.013; IL-18: OR 2.6 [95CI: 1.02–6.63], p = 0.045). This evidence concerns the gene IL18 and neoplasm.