Indeed, in human, a transcriptomic study has found that the expressions of NLRP1 (NOD-like receptor family pyrin domain containing 1), NLRP3, NLRC4 (NLR Family CARD Domain Containing 4 ) and AIM2 (Absent in Melanoma 2) were reduced in Chinese patients with CRC [8]. The gene discussed is AIM2; the disease is colorectal carcinoma.