NOD2 and colorectal cancer: Furthermore, through transcriptome analyses of bulk tumors from public databases, Liu et al. found three different patterns of inflammasome expression in colorectal cancer: a downregulation for NLRP1, NLRP3, NLRC4 and AIM2, an upregulation for NOD1 and NOD2 and no variation for NLRC5, NLRP6 and NLRP12 [8].