Interestingly, the existence of crosstalk between TREM2 and canonical Wnt signalling in microglia had already been discovered in an earlier mouse study [134], where it was demonstrated that the proliferative response of activated microglia not only requires TREM2 but also crosstalks with canonical Wnt signalling [134]; although not explicitly addressed within this study, it appears plausible that the same would apply to microglial proliferation in human AD brain. The gene discussed is TREM2; the disease is Alzheimer disease.