PSEN1 and Alzheimer disease: In addition, collective evidence suggests that ApoE also interacts with Wnt signalling pathways in an AD-relevant manner: ApoE4-mediated Aβ pathology in the APP/PS1 AD mouse model required the expression of its neuronal receptor LRP1 [129], which had previously been found to suppress Wnt3a-driven canonical Wnt signalling in HEK cells by interacting with Fz1 [130].