ELOVL5 and Refsum disease: Mutations in very long chain fatty acid elongase 4 and 5 (Elovl4 and ElovL5) are reported to cause spinocerebellar ataxia [51,52,53] and accumulation of the branched-chain acid fatty acid was reported to be associated with Refsum disease caused by mutations in Phytanic acid alpha-oxidation (in AOA gene panel) [54].