These gene mutations included: ATP1A3 (associated with the expanding phenotypic spectrum of alternating hemiplegia of childhood, rapid-onset dystonia-parkinsonism, CAPOS and FIPWE) [18], POLG (mitochondrial depletion syndrome), NPC1 (Niemann–Pick disease, type C1), TUBB4A (DYT4), MTTP (abetalipoproteinemia), SPG7 –(spastic paraplegia 7) and SLC2A1 (GLUT1 deficiency syndrome). This evidence concerns the gene TUBB4A and Spastic paraplegia.