In histologic features, multifocal bile ductular proliferation, histologic atypia, and invasive intestinal-type CCA were chronologically determined, and similar expression patterns of c-Met and c-ErbB-2, EGFR, apomucins, and MMPs (Matrix metallopeptidases) were detected in rat TAA-induced iCCAs and human CCAs, suggesting that the progression of TAA-induced iCCA can mimic the multistep model of human CCA. Here, MET is linked to cholangiocarcinoma.