We found that some key proteins related to the complement system and F. gigantica infection, including E1BD43 (gene symbol: AOC3; protein: amine oxidase), F1N045 (gene symbol: C7; protein: complement component C7), and F2X047 (gene symbol: LYZ; protein: lysozyme), were differentially expressed in sera of infected buffaloes at all three time points of infection [11]; these proteins were upregulated in infected hLNs at three dpi, but their differential expressions were not observed at 42 and 70 dpi. This evidence concerns the gene LYZ and infection.