RAS mutations have been found in several B-ALL subtypes, including TCF3-ZNF384-rearranged B-ALL [59], hypodiploid [6], high hyperdiploid [8], Pax5alt [78] and P80R [70], TCF3-HLF-rearranged B-ALL [96], Ph-like [24] and iAMP21 B-ALL [42]. The gene discussed is TCF3; the disease is acute lymphoblastic leukemia.