RB1 and acute lymphoblastic leukemia: Near-haploid ALL is characterized by genetic alterations involving Ras signaling pathway, Receptor Tyrosine Kinase (RTK) signaling and IKZF3 [6], whereas CDKN2A/B, IKZF2 and RB1 alterations or TP53 germline mutations are frequently found in low-hypodiploid ALL [10].