In DUX4-rearranged B-ALL, additional recurrent genomic alterations affect the lymphoid transcription factor genes IKZF1 and PAX5. Mutations were detected also in transcription factors and transcriptional regulators including MYC, MYCBP2, MGA and ZEB2, in genes involved in activation of Ras signaling, cell cycle regulation, and epigenetic modifiers including KMT2D, SETD2, ARID2 and NCOR1 [63,65]. The gene discussed is DUX4; the disease is precursor B-cell acute lymphoblastic leukemia.