Gene expression profiling revealed a significant biological similarity of these ETV6-RUNX1-negative B-other ALL cases to ETV6-RUNX1-positive ALL, since 5 out of 7 cases clustered within the ETV6-RUNX1-positive subtype and, therefore, were classified as ETV6-RUNX1-like ALL. Here, ETV6 is linked to acute lymphoblastic leukemia.