ABCA12 and autosomal recessive congenital ichthyosis: With the exception of the severe HI, which is mainly due to ABCA12 mutations, LI, CIE, and SICI phenotypes may occur as a consequence of pathogenic variants in most of the known ARCI genes, thereby making difficult clinical and molecular classification of the different types of ARCI [1,2,3,4,5,6,9,10,11].