Here, we demonstrate that bMSC cultured in MGS and RPM in the presence of an osteogenic cocktail overexpress some osteogenic markers, i.e., RUNX2, Sp7, and COL1A1. Interestingly, culture in the MGS performs better than RPM in inducing bMSC osteogenic response to OM. This evidence concerns the gene COL1A1 and ocular melanoma.