A humanized monoclonal anti-TSLP antibody, tezepelumab, which blocks the interaction of TSLP with TSLPR recently completed a phase 2 clinical trial for uncontrolled, severe asthma where tezepelumab-treated individuals displayed significant reduction in asthma exacerbation rate together with improved lung function and asthma control [145]. The gene discussed is TSLP; the disease is asthma.