However, Lu et al. reported that C26-bearing mice orally treated with ginsenoside Rg1 (10.72 mg/kg in Phosphate-buffered saline (PBS) solution for 23 days from the onset of cachexia) had neither the protection of body weight nor gastrocnemius muscle mass but only reduced levels of TNFα and IL-6, further confirming that solely inhibition of proinflammatory pathways is not sufficient to block CC [256]. This evidence concerns the gene TNF and cholangiocarcinoma.