To test the effects of antioxidants such as α-lipoic acid, N-acetylcysteine (NAC), and amifostine, ROS levels and antioxidant enzymes, such as GPx and SOD, have been measured in blood of patients with cachexia and ROS found to be increased, while GPx and SOD decreased, overall resulting in OS increase [99]. This evidence concerns the gene SOD1 and Cachexia.