Surprisingly, even if glycyrrhizin is known to inhibit HMGB1 [260], which seems increased in plasma and muscles of cachectic C26 mice [13] but not in muscles of LLC-bearing ones [261], it is still not clear whether the beneficial effects of this molecule against cachexia are related to the inhibition of HMGB1. Here, HMGB1 is linked to Cachexia.