The BDNF/TrkB pathway activates downstream pathways such as PI3K/Akt, and is associated with key oncogenic outcomes in a variety of adenocarcinomas, including lung [14], breast [15], gastric [16], colorectal [17] and salivary gland adenoid cystic carcinoma [18,19]. The gene discussed is NTRK2; the disease is adenocarcinoma.