Further studies demonstrated that IFI16 has DNA sensor activity in the nucleus after different types of infections with nuclear-replication DNA viruses, including HSV-1 [9,10,28], KSHV [11], and HCMV [30], as well as after retrovirus infection, recognizing DNA intermediates of human immunodeficiency virus 1 (HIV-1) [6,62]. Here, IFI16 is linked to infection.