Melancholic depression is characterized by a lower absolute monocyte count, increased haptoglobin, IL-6 and CRP, enhanced expression of T cell activation markers, and increased resistance of sIL-2R and IL-1β production in response to dexamethasone administration as compared to non-melancholic depression [426,427,428,429,430,431]. The gene discussed is CRP; the disease is melancholia.