Regarding the systems via which miR-21 could exercise its effects on osteoporosis, researchers demonstrated that an increase of miR-21 augmented RANKL generation and reduced TGF-Beta 1 and OPG concentrations, and this was able to provoke an augment of RANKL/OPG ratio with a rise of bone reabsorption and reduction of BMD, producing osteoporosis [88]. This evidence concerns the gene TGFB1 and osteoporosis.