Additionally, dysplasia (p < 0.02) and hyperplasia (Figure 3B, p = 0.076) were more severe in the colon of Hh+Hp males at 21 WPI compared to 10 WPI; there were no significant differences in severity of colonic dysplasia and hyperplasia in mono-Hh females between these two time-points (Figure 3B, p > 0.1). This evidence concerns the gene HP and colon dysplasia.