At 21 WPI, colonic dysplasia was significantly more severe in Hh+Hp males compared to mono-Hh males (Figure 3B, p = 0.02); inflammation (p = 0.086), edema (p = 0.06) and hyperplasia (p = 0.08) in Hh+Hp males tended to be more severe than those in mono-Hh males. This evidence concerns the gene HP and colon dysplasia.