MIPPS70+ version 2.0 includes five genetic and four clinical variables: very high risk (VHR) karyotype (4 points), unfavorable karyotype (3 points), presence of one (2 points) or ≥2 HMR mutations (3 points), absence of type 1/like CALR mutation (2 points), constitutional symptoms (2 points), severe anemia (2 points), moderate anemia, (1 point) and circulating blasts ≥2% (1 point). Here, CALR is linked to anemia.