The goal of the present study was to evaluate the sensitivity, specificity, and the best accuracy level of sFlt-1, PlGF, sFlt-1/PlGF ratio in maternal serum and protein/creatinine ratio in urine sample to define the best cutoff point of these tests to discriminate between the patients with gestational hypertension and the patients with pre-eclampsia, to evaluate the possibility of using them as diagnostic methods. The gene discussed is PGF; the disease is preeclampsia.