PGF and endothelial dysfunction: The damaged placenta produces higher concentrations of Soluble fms-like tyrosine kinase-1 (sFlt-1), a soluble receptor for vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) that is released into the maternal circulation and is involved in endothelial dysfunction.8, 9, 10, 11Soluble fms-like tyrosine kinase-1 is an endogenous antiangiogenic protein that is made by the placenta and acts by binding and neutralizing the proangiogenic proteins VEGF and PlGF.