2015), and against LPS-induced inflammation in microglial cells (Li C et al. 2018). Nrf2 is also known for improving blood–brain barrier integrity from LPS-induced disruption in mice (Li H et al. 2018). In this study, we reported increased protein expression of Nrf2 and its downstream signal molecule HO-1 in the myocardial tissue of HF rats. Such a result was consistent with recently published data showing that ASI induced Nrf2/HO-1 protein expressions in the myocardium in a rat model of abdominal aortic constriction (Nie et al. 2019). This evidence concerns the gene HMOX1 and hydrops fetalis.