HMOX1 and metabolic dysfunction-associated steatotic liver disease: The results of this study showed that the expression of Nrf2 and HO-1 in the liver tissue of mice treated with the different doses of wogonoside was significantly increased compared with that in NAFLD group, further confirming that wogonoside can protect NAFLD mice from the liver injury by regulating the Nrf2/HO-1 pathway and inhibiting the oxidative stress.