Western blot analysis showed that the expression of Nrf2 and HO-1 proteins in the liver tissue of mice in NAFLD group was significantly lower than that in the control group (p < 0.01), and the expression of Nrf2 and HO-1 proteins in the liver tissue of mice in the low-, medium- and high-dose wogonoside groups was significantly higher than that in NAFLD group (p < 0.01), as shown in Figure 6(d–f). This evidence concerns the gene HMOX1 and metabolic dysfunction-associated steatotic liver disease.