Genome- wide association studies have already started to identify the association of Ifit2 in the disease pathogenesis of autoimmune Systemic lupus erythematosus (SLE) [66], Multiple Sclerosis (MS) [67], Amyotrophic Lateral Sclerosis (ALS), Alzheimer (AD) and Parkinson’s disease (PD)[68] and providing new insights into the specifications of ISG actions. The gene discussed is IFIT2; the disease is amyotrophic lateral sclerosis.