CFTR and cystic fibrosis: Apart from the usual suspects of immune and vesicle trafficking processes and pathways reported in previous publications, including a large number of pathways dominated by HLA genes [11, 12, 79, 80], some highly specific, pathogenically relevant processes were also enriched, with examples of “Interferon-gamma-mediated signaling pathway” from GO biological process, “Defective CFTR causes cystic fibrosis” and “Antimicrobial peptides” from Reactome pathway, and “Asthma” from KEGG pathway shown in Fig 6 (and in S1, S2 Tables in S4 File).