Thus, both GWAS loci and non-GWAS loci contain genes that mark functions important in the pathogenesis of CF lung disease, such as immunity/infection/inflammation, virus/viral, and mucociliary clearance; and in CFTR biology, such as cytoskeleton, microtubules, mitochondria, lipid, ubiquitination, and ER and Golgi compartments. This evidence concerns the gene CFTR and lung disorder.