The strength of association and causality between smoking and MS risk has been suggested due to a dose-dependent relationship in duration and intensity of smoking [4,34] as well as from the interaction between compounds present in cigarettes and specific genetic HLA variants, which include the presence of HLA-DRB1*15, the absence of HLA-A*0201 [35], and specific N-acetyltransferase 1 (NAT1) polymorphisms [36]. Here, HLA-DRB1 is linked to myeloid sarcoma.