For example, in gastric cancer, TGF‐β‐activated HSCs secrete lysyl oxidase (LOX), which contributes to the fibrotic niche by crosslinking collagen fibers and increasing tumor cell proliferation through an AKT‐p70S6K‐hypoxia‐inducible factor(HIF)1‐α pathway.106. This evidence concerns the gene LOX and gastric cancer.