Cytokines, secreted by Kupffer cells as well as by arrested tumor cells, can lead to increased adhesion and extravasation of the tumor cells to the sinusoid endothelium, through induced expression of certain adhesion molecules on LSECs, including E‐selectin, vascular cell adhesion molecule‐1, and intracellular adhesion molecule (ICAM)‐1.39, 42, 43, 44, 45, 46, 47. The gene discussed is ICAM1; the disease is neoplasm.