For example, VEGF, PLGF, MMP‐10, MMP‐3, Angpt2, and PTHLH released from tumor cells in various types of tumors are capable of triggering pulmonary endothelium hyper‐permeability, thereby accelerating extravasation of tumor cells.29, 36, 37, 38. The gene discussed is PGF; the disease is neoplasm.