For example, VEGF, PLGF, MMP‐10, MMP‐3, Angpt2, and PTHLH released from tumor cells in various types of tumors are capable of triggering pulmonary endothelium hyper‐permeability, thereby accelerating extravasation of tumor cells.29, 36, 37, 38. Here, ANGPT2 is linked to neoplasm.