It has been recently unveiled that the activation of NOD‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome in macrophages and the production of the proinflammatory cytokines interleukin (IL)‐1β and IL‐18 play a critical role in pyroptosis of macrophages during ALI;7, 8 however, the regulatory mechanisms of NLRP3 inflammasome in ALI have not been completely addressed. This evidence concerns the gene NLRP3 and acute respiratory distress syndrome.