More importantly, several quite new studies, which reported CASC11 could promote proliferation, migration, invasion, epithelial‐mesenchymal transition, and chemoresistance of HCC cells,13, 14, 15 highlighted the impressive significance of CASC11 in HCC, whereas left the clinical signification and underlying mechanism of affecting hepatocarcinogenesis in vitro and in vivo to be fully unfolded. Here, CASC11 is linked to hepatocellular carcinoma.