Crosstalk between M2 macrophages and Tregs, immunosuppressive factors of the TME (TGF‐β, IL‐10, IDO1), and tumor antigen PD‐L1 cause CD8+ T‐cell inactivation and contribute to inefficient CD8+ T‐cell response priming [34]. The gene discussed is TGFB1; the disease is neoplasm.