Tumor-released oxysterols can also act in an LXR-independent, (C-X-C motif) chemokine receptor 2 (CXCR2) dependent way to recruit neutrophils within the tumor microenvironment where they act to suppress tumor-specific T-cells and promote neo-angiogenesis (Raccosta et al., 2013, 2016). The gene discussed is CXCR2; the disease is neoplasm.