However, expression of genes involved in sterol catabolism (CYP8B1, CYP27A1, CYP7B1, CYP39A1) and sterol efflux (ABCA1, ABCG5, ABCG8) was significantly reduced in HCC tissues implying that sterols accumulate in HCC (Lu et al., 2013). This evidence concerns the gene ABCG8 and hepatocellular carcinoma.