The homeostasis model assessment index (a measure of insulin resistance) decreased significantly (−1.3; 95% CI, −2.2 to −0.3; P < .001), and PREDIM (a measure of insulin sensitivity) increased significantly in the intervention group (0.9; 95% CI, 0.5-1.2; P < .001); neither changed significantly in the control group (Table 2). This evidence concerns the gene INS and Insulin resistance.