CD244 and infection: Accordingly, on day 9 post-LCMV-CL13 infection, virus-specific CD8 TEFF from anti-LFA-1 Mab treated mice had markedly upregulated PD1, LAG3, and 2B4, while virus-specific CD8 TEFF from infected control mice expressed moderate levels of 2B4, but not PD-1 or LAG3 (Figure 2(d)).