RA synovial fibroblasts are hyperplastic and proliferate faster than non‐RA synovial fibroblasts, resulting in the formation of pannus‐like structures as they lose contact inhibition, become anchorage‐independent and upregulate expression of collagenases such as matrix metalloproteases and aggrecanases including ADAMTS4/5 that promotes cartilage degradation and perpetuate inflammation of the joint [25]. Here, ADAMTS4 is linked to rheumatoid arthritis.