High levels of glycolytic enzyme PGK1 were observed in the blood and synovial tissue of RA patients and silencing of PGK1 in RA synovial fibroblasts using anti‐PGK1 siRNA reduced the secretion of pro‐inflammatory cytokines IL‐1β and IFN‐γ [34]. This evidence concerns the gene PGK1 and rheumatoid arthritis.