Inhibiting PFKFB3 glycolytic enzyme in RA synovial fibroblasts with 3PO (dipyridinyl‐propenone), a small molecule compound, which selectively inhibits PFK‐2 activity of the PFKFB3 enzyme, reduced fructose‐2,6‐bisphosphate and lactate levels as well as reducing the secretion of pro‐inflammatory cytokines [36]. The gene discussed is HK1; the disease is rheumatoid arthritis.