CBX8 and cancer: ,14 However, the low activity of WNK2 in cancer is associated with low levels of expression rather than changes in gene sequence, indicating that an epigenetic mechanism is involved in the regulation of WNK2. 15CBX8 mutations are rarely reported, whereas overexpression of CBX8 is widely found in various cancers.22, 23, 24,28,29 Overexpressed CBX8 may function in cancer by suppressing antioncogenes.