CBX8 acts as an oncogene and is involved in tumor progression.21, 22, 23 Alterations in CBX8 are observed in many cancers, such as glioblastoma, colorectal cancer (CRC), breast cancer, leukemia, and hepatocellular carcinoma.22, 23, 24,28,29 Specifically, CBX8 promotes proliferation, differentiation, invasion, and metastasis, promoting breast tumorigenesis and increasing proliferation in CRC.22 Here, CBX8 is linked to cancer.