Likewise, fibrogenesis as evidenced by the Picrosirius Red collagen staining (Figure 3A), was more pronounced in IUGR-MSCs, as shown by higher expression of COL1A1, a major component of type I collagen (P < 0.03; Figure 3B), 3 days after the induction of differentiation of IUGR- compared to Normal-MSCs. This evidence concerns the gene COL1A1 and fetal growth restriction.