Contrary to what was observed for adipogenesis and fibrogenesis, IUGR-MSCs had reduced osteogenic capacity compared to Normal-MSCs, as indicated by lower expression of RUNX2 and ALP (a transcription factor and a osteogenic marker, respectively; P < 0.02; Figures 4B,C) after 12 days of differentiation in IUGR-MSCs. This evidence concerns the gene RUNX2 and fetal growth restriction.