It is already shown that loss of PHF6 expression in B-ALL cells can induce a partial switch toward the T cell lineage (Soto-Feliciano et al., 2017) and additional recent data support a role for PHF6 in murine hematopoietic stem and progenitor cell homeostasis (McRae et al., 2019) and renewal (Miyagi et al., 2019). The gene discussed is PHF6; the disease is acute lymphoblastic leukemia.