Accumulating evidence suggests that PTEN plays a critical role in cardiovascular disease by inhibiting AKT-dependent pathways (GSK3, FOXO, and mTOR) and PINK1-AMPK signaling cascades (Crackower et al., 2002; Song et al., 2012; Xu et al., 2014; Roe et al., 2015). This evidence concerns the gene AKT1 and cardiovascular disorder.