Recently, we demonstrated that GA administration improved pressure overload-induced myocardial hypertrophic remodeling (including hypertrophy, fibrosis, inflammation, and oxidative stress) (Yan et al., 2019) and Ang II-induced hypertension and vascular dysfunction (Yan et al., 2020), suggesting that GA may exert a protective effect on AF. This evidence concerns the gene AGT and atrial fibrillation.