Studies have reported that cannabinoid type 2 receptor (CB2) and G-protein-coupled receptor 55 (GPR55), as G-protein-coupled receptors, were both increased in psoriasis vulgaris and could attenuate oxidative stress and act in an anti-inflammatory process (Ambrożewicz et al., 2018; Figure 3). This evidence concerns the gene GPR55 and psoriasis vulgaris.