GO analysis revealed that, compared with PN or NN, hypermethylated DMRs in PP were particularly associated with response-related items [e.g., defense response, response to other organisms, inflammatory response, and response to (external) biotic stimulus] and cytokine-related items (e.g., regulation of cytokine production, cytokine production, and interleukin-6 production), suggesting that these hypermethylated DMRs may be involved in the response to environmental stimulations at the initial stage of psoriasis vulgaris (Figure 2B, Supplementary Figure 5A, and Supplementary Data 3). The gene discussed is IL6; the disease is psoriasis vulgaris.