It has been shown that antioxidants such as N-acetylcycteine and vitamin C inhibit MYC-driven lymphoma xenograft growth in vivo by targeting HIF1, which can be rescued by the expression of oxygen-independent HIF1 mutant (Gao et al., 2007), supporting a key role of HIF1 in MYC-driven tumors. Here, MYC is linked to lymphoma.