Similarly, high levels of N-MYC in N-MYC amplified neuroblastoma cells override HIF1α inhibition of cell cycle progression under hypoxia and cooperates with HIF1α to promote the expression of phosphoglycerate kinase 1 (PGK1), HK2, and LDHA (Qing et al., 2010). The gene discussed is MYCN; the disease is neuroblastoma.