In addition to common targets regulated by both HIF-1α and HIF-2α, HIF-2α also stimulates the expression of specific genes involved in cell cycle progression, amino acid and lipid metabolism, angiogenesis and vasculature remodeling, tumor growth, metastasis, stemness as well as regulating tumor microenvironment (Covello et al., 2006; Keith et al., 2011; Elorza et al., 2012; Rankin and Giaccia, 2016; Hoefflin et al., 2020). The gene discussed is EPAS1; the disease is neoplasm.