Instead, HS-27A cell line could represent the negative control, as the majority of the gene signatures involved in the pro-tumor activity mediated by primary MSCs resulted down-modulated in this cell line, such as those regulating “angiogenesis,” “Wnt/β catenin signaling,” “KRAS signaling” and “PI3K-AKT-mTOR signaling” (Wang et al., 2015; El-Badawy et al., 2017; Poggi et al., 2018; Adamo et al., 2019a). Here, MTOR is linked to neoplasm.