Hui et al. (2017) reported that mice with adipose tissue specific ablation of SIRT1 are more susceptible to insulin resistance and argued adipocyte SIRT1 plays an important role in glucose homeostasis through modulation of macrophages. We observed a significant increase of SIRT1 in Sq- and HH-Sq-treated adipocytes, which suggests improved glucose homeostasis. Here, SIRT1 is linked to Insulin resistance.