TNBS (del Carmen et al., 2013) or DSS (Zurita-Turk et al., 2014) were used to induce IBD in mice; the animals that received L. lactis FnBPA+(pValac:IL-10) showed lower damage scores in their large intestines (at both macroscopic and microscopic levels), reduced microbial translocation to the liver, and increased anti-inflammatory/pro-inflammatory cytokine ratios compared to mice that received L. lactis FNBPA+ without the pValac:IL-10 plasmid. Here, IL10 is linked to inflammatory bowel disease.