Among the 132 antigenic proteins recognized by antibodies present in sera from patients with histoplasmosis, five protein entries were specifically recognized by these antibodies, without cross-reaction with antibodies present in sera from other conditions (Figure 2B and Table S5), namely: catalase (C0NVF6), catalase B (Q9Y7C2), M antigen (O13373), Yeast phase specific protein (Q8J1T0), and YPS-3 protein (Q00950). This evidence concerns the gene CAT and histoplasmosis.