TP53 and cancer: Some cancer-related gene sets were significantly gathered in HCC patients with high risk score, including “DNA repair,” “MYC targets V1,” “mTORC1 signaling,” “PI3K-AKT-mTOR signaling,” “glycolysis,” “G2M checkpoint,” “E2F targets,” “Wnt/beta-catenin Signaling,” “P53 pathway,” shown in Figure 11.