The six key RBP genes were analyzed by using Kaplan–Meier curve analysis to further verify their prognostic value on the TCGA cohort, and the results demonstrated that HCC patients with UPF3B and CNOT6 low-expressions had longer OS, while patients with IFIT5, MRPL54, PPARGC1A, and ZC3H13 high-expression had better survival rate (Figure 5C). This evidence concerns the gene UPF3B and hepatocellular carcinoma.