Based on the previously obtained six key prognosis-related RBP genes, we established a risk core model, and the risk score of each HCC patients was calculated using the formula: Risk score = (0.34900 × CNOT6 Exp) + (0.50277 × UPF3B Exp) + (-0.43143 × MRPL54 Exp) + ( -0.21809 × ZC3H13 Exp) + ( -0.46413 × IFIT5 Exp) + ( -0.19919 × PPARGC1A Exp). This evidence concerns the gene CNOT6 and hepatocellular carcinoma.