Alternatively, upregulated MMP-2 and MMP-9 expression might be caused by abnormal metabolic stimuli resulting from the presence of diabetes, which is known to induce the dysfunction of several intracellular signal transduction cascades; for example, protein kinase activity and the accumulation of advanced glycation end products might induce the generation of MMP overproduction under diabetic conditions (64–68). Here, WEE1 is linked to diabetes mellitus.