Study results revealed that gal-9 signaling is concerned with regulatory functions in autoimmunity via T-cell immunoglobulin mucin 3 (TIM-3) or other yet to be identified receptors, accompanied by altering macrophages to an anti-inflammatory, down-regulating the number of effector T cells and increasing the number of regulatory T cells (Tregs) (3–5). Here, LGALS9 is linked to Autoimmunity.