Collectively, these clinical data suggest that the combination of bevacizumab and atezolizumab in patients with primary or secondary liver cancers may thwart the induction of immunosuppressive immune cell types (e.g., MDSCs, Tregs, and TAMs) that are induced by tumor hypoxia, VEGF overexpression, or increased hepatic angiogenesis (50). This evidence concerns the gene VEGFA and neoplasm.