Six patients suffered from severe combined immune deficiency (SCID) (γC deficiency n= 1, IL-7 receptor deficiency n= 1, JAK 3 deficiency n= 1, RAG-1 deficiency n= 2 and RAG-2 deficiency n= 1), and six had a combined immune deficiency (MHC class II deficiency n= 1, ZAP-70 deficiency n= 2, hypomorphic ARTEMIS deficiency n= 1, and combined immune deficiency with an unknown molecular diagnosis n= 2). This evidence concerns the gene ZAP70 and Immunodeficiency by defective expression of HLA class 2.