Different from the genetic disease cystic fibrosis (CF) caused by the mutations in the CF transmembrane conductance regulator, it is well recognized that tobacco smoking is the main causal and primary inciter for the formation of COPD (Rab et al., 2013; Lange et al., 2015; De Rose et al., 2018). The gene discussed is CFTR; the disease is cystic fibrosis.