Compared with PAO1, more than half of the COPD isolates harbored non-synonymous SNPs in the genes significantly enriched (p < 0.05) in the KEGG terms of glyoxylate and dicarboxylate metabolism (15 isolates), bacterial secretion system (14 isolates), and microbial metabolism in diverse environments (13 isolates) (Figure 2C and Supplementary Dataset 4). This evidence concerns the gene SMOX and chronic obstructive pulmonary disease.