Previous studies have also showed that the maintenance of negative behaviors (i.e.: physical inactivity, sedentary behavior, and unhealthy food consumption) for few weeks result in deleterious effects on metabolic (increases in insulin resistance, total body fat, abdominal fat and inflammatory cytokines), immune function (immunosenescence), and cardiovascular parameters (blood pressure and heart rate increase, endothelial function reduction, etc...) that impact the management of diabetes and others NCDs (10, 20–22). Here, INS is linked to diabetes mellitus.