TARDBP and Alzheimer disease: CBS-CBD and CBS-PSP pathology: focal atrophy involving premotor cortex, posterior superior frontal lobe and supplementary motor area (SMA), CBS-TDP-43, and CBS-AD pathology: more widespread gray matter loss, CBS-TDP43 pathology: fronto-temporal involvement (particularly prefrontal cortex) and CBS-AD pathology: temporo-parietal involvement (particularly parietal cortex) (39).