DYSF and autosomal recessive limb-girdle muscular dystrophy type 2B: Limb-girdle muscular dystrophy type 2B (LGMDR2) and Miyoshi myopathy (MM) caused by variants in the dysferlin gene, DYSF (146), are the two major clinical types of dysferlinopathy (147), characterized by proximal muscle-weakness, difficulty in running and climbing stairs, and increased fatigue (148).