Dysferlinopathy-specific features: Absent Dysferlin stain in muscle immunohistochemistry (IHC), and disease-range blood monocyte assay for DYSF protein estimation; difficulty running, change in gait, wasting of calves, biceps lump; most-affected muscles: Gastrocnemius, Iliopsoas, hip adductors, hamstrings, and quadriceps. The gene discussed is DYSF; the disease is neuromuscular disease caused by qualitative or quantitative defects of dysferlin.